Synaptic Vesicle Dynamics

The laboratory investigates the fundamental aspects of synaptic vesicle recycling related to neurological and neurodegenerative diseases using mouse and mammalian cells as a model system. Cutting edge genomic engineering is combined with the latest imaging and cell biological techniques to study the processes that regulate synaptic vesicle formation. In a distinct but related strand of work, we are exploring the signaling processes that arise from altered neurotransmission and lead to neurodegeneration.

Selected recent publications:

  • Yambire KF, Fernandez-Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, Raimundo N (2019) Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. Elife. Feb 18;8. pii: e39598. doi: 10.7554/eLife.39598

  • Kroll J, Jaime Tobón LM, Vogl C, Neef J, Kondratiuk I, König M, Strenzke N, Wichmann C@, Milosevic I@, Moser T@ (2019) Endophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells. EMBO J 38(5). pii: e100116. doi: 10.15252/embj.2018100116.

  • Fernandez-Mosquera L, Yambire KY, Couto R, Pereyra L, Stagi M, Milosevic I, Raimundo N. (2018) Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis. (2018) Autophagy, in press

  • Watanabe S, Mamer LE, Raychaudhuri S, Luvsanjav D, Eisen J, Trimbuch T, Söhl-Kielczynski B, Fenske P, Milosevic I, Rosenmund C, Jorgensen EM (2018) Synaptojanin and endophilin mediate neck formation during ultrafast endocytosis. Neuron 98(6), 1184-1197

  • Farsi Z, Gowrisankaran S, Matija K, Rammner B, Woehler A, Mim C, Jahn R, Milosevic I@ (2018) Clathrin coat controls vesicle acidification by blocking vacuolar ATPase activity. eLife 7, doi: 10.7554/eLife.32569

Our work is supported by the German Research Foundation (DFG; Emmy Noether award), Alexander von Humboldt (AvH) Foundation, Schram Foundation, Engelhorn Foundation, SB889 and SFB1190.